Inflammation-associated Cancer: NF-kappaB Is the Lynchpin

Trends Immunol. 2005 Jun;26(6):318-25. doi: 10.1016/j.it.2005.04.003.

Abstract

It has long been suspected that NF-kappaB signaling has a pivotal role in chronic inflammation-associated malignancies, although genetic evidence for this hypothesis has been lacking. However, recent papers have lent credence to this concept and show that NF-kappaB activation in pre-malignant cells contributes to cell survival and metastatic potential. Furthermore, NF-kappaB activation in tumor-associated leukocytes, especially macrophages, contributes towards tumorigenesis by upregulating tumor-promoting proinflammatory proteins. This emphasizes the importance of NF-kappaB inhibitors as immunotherapeutic agents for chronic inflammation and suggests that these reagents might prevent, or at least inhibit, chronic inflammation-associated tumorigenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Cytokines / antagonists & inhibitors
  • Cytokines / immunology
  • Cytokines / therapeutic use
  • Humans
  • Inflammation / complications
  • Inflammation / metabolism
  • Inflammation / pathology
  • Inflammation / therapy
  • Leukocytes / immunology
  • Leukocytes / pathology
  • NF-kappa B / metabolism*
  • Neoplasms / complications*
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Neoplasms / therapy

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cytokines
  • NF-kappa B