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, 7 (7-8), 1040-8

CD40 Ligation Prevents Onset of Tolerogenic Properties in Human Dendritic Cells Treated With CTLA-4-Ig

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CD40 Ligation Prevents Onset of Tolerogenic Properties in Human Dendritic Cells Treated With CTLA-4-Ig

Carmine Vacca et al. Microbes Infect.

Abstract

The synthetic immunomodulator cytotoxic T lymphocyte antigen 4-Ig (CTLA-4-Ig) initiates effects in human monocyte-derived dendritic cells (DC) that rely on immunosuppressive tryptophan catabolism. However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4.

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