Assessment of neurolymphomatosis by brachial plexus biopsy and PET/CT. Report of a case

J Neurooncol. 2005 Apr;72(2):163-7. doi: 10.1007/s11060-004-3389-0.


Objective: To report a biopsy-proven neurolymphomatosis in a young woman with previous non-Hodgkin's lymphoma (NHL) of uterine cervix.

Patient: The patient presented with a painful brachial plexopathy and developed multiple cranial and spinal nerve palsies.

Methods and results: The diagnosis was achieved by an open brachial plexus biopsy. A PET/CT study was used to assess the full extent of the disease and showed involvement of additional cranial nerves and spinal nerve roots. A complete although short lasting clinical and radiological response was achieved by means of systemic high dose methotrexate treatment combined with rituximab and intra-CSF injections of cytarabine.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Brachial Plexus / pathology*
  • Cranial Nerves / pathology
  • Female
  • Humans
  • Lymphatic Metastasis
  • Lymphoma, Non-Hodgkin / complications
  • Lymphoma, Non-Hodgkin / diagnosis*
  • Lymphoma, Non-Hodgkin / pathology*
  • Paralysis / etiology
  • Positron-Emission Tomography
  • Spinal Nerve Roots / pathology
  • Tomography, X-Ray Computed
  • Uterine Cervical Neoplasms / pathology*