Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities

Eur J Med Chem. 2005 Aug;40(8):737-50. doi: 10.1016/j.ejmech.2004.10.016.


Adrenomedullin (AM) is a 52-amino acid peptide with a pluripotential activity. AM is expressed in many tissues throughout the body, and plays a critical role in several diseases such as cancer, diabetes, cardiovascular and renal disorders, among others. While AM is a protective agent against cardiovascular disorders, it behaves as a stimulating factor in other pathologies such as cancer and diabetes. Therefore, AM is a new and promising target for the development of molecules which, through their ability to regulate AM levels, could be used in the treatment of these pathologies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenomedullin
  • Amino Acid Sequence
  • Animals
  • Antihypertensive Agents / pharmacology*
  • Cardiovascular Diseases / drug therapy*
  • Diabetes Mellitus / drug therapy*
  • Drug Design*
  • Humans
  • Molecular Sequence Data
  • Neoplasms / drug therapy*
  • Peptides / drug effects*
  • Peptides / physiology
  • Sequence Alignment


  • Antihypertensive Agents
  • Peptides
  • Adrenomedullin