The dual glutamatergic-GABAergic phenotype of hippocampal granule cells

Trends Neurosci. 2005 Jun;28(6):297-303. doi: 10.1016/j.tins.2005.04.005.


Markers of the glutamatergic and GABAergic phenotypes coexist in developing hippocampal granule cells, and activation of these neurons produces simultaneous glutamate-receptor-mediated and GABA-receptor-mediated responses in their postsynaptic cells. In the adult, markers of the GABAergic phenotype and the consequent GABAergic transmission disappear but can be transiently expressed in an activity-dependent manner. Coexistence of glutamate and GABA in neurons from other regions of the brain is being discovered, and the possibility of these neurotransmitters being co-released gives the CNS a powerful computational tool. Although waiting to be confirmed by paired recordings, the hypothesis that glutamate and GABA are co-released from single cells is a valuable heuristic proposal in understanding the plasticity inherent to neuronal communication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Glutamic Acid / metabolism*
  • Hippocampus / cytology*
  • Models, Neurological
  • Neurons / metabolism*
  • Phenotype*
  • Synapses / physiology
  • Synaptic Transmission / physiology
  • gamma-Aminobutyric Acid / metabolism*


  • Glutamic Acid
  • gamma-Aminobutyric Acid