Impaired and repaired inhibitory circuits in the epileptic human hippocampus

Trends Neurosci. 2005 Jun;28(6):334-40. doi: 10.1016/j.tins.2005.04.002.


This review focuses on the epileptic human temporal lobe, primarily on recent findings related to changes in hippocampal GABAergic interneuron circuits that have a central role in epileptogenesis. Relying on correlations to animal studies, we provide a functional interpretation of the different changes in perisomatic inhibition (controlling output synchrony) and dendritic inhibition (controlling input plasticity), and the potential consequences of the loss of interneuron-selective interneurons. The highly heterogeneous, but specific, alterations of GABAergic interneuron circuits have important implications for the pharmacotherapy of epilepsy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calbindins
  • Epilepsy / physiopathology*
  • Hippocampus / pathology
  • Hippocampus / physiopathology*
  • Hippocampus / ultrastructure
  • Humans
  • Interneurons / pathology
  • Interneurons / ultrastructure
  • Nerve Net / physiopathology*
  • Neural Inhibition / physiology*
  • Neuronal Plasticity / physiology*
  • Parvalbumins / metabolism
  • Recovery of Function / physiology*
  • S100 Calcium Binding Protein G / metabolism
  • gamma-Aminobutyric Acid / metabolism


  • Calbindins
  • Parvalbumins
  • S100 Calcium Binding Protein G
  • gamma-Aminobutyric Acid