Annexins: linking Ca2+ signalling to membrane dynamics

Nat Rev Mol Cell Biol. 2005 Jun;6(6):449-61. doi: 10.1038/nrm1661.


Eukaryotic cells contain various Ca(2+)-effector proteins that mediate cellular responses to changes in intracellular Ca(2+) levels. A unique class of these proteins - annexins - can bind to certain membrane phospholipids in a Ca(2+)-dependent manner, providing a link between Ca(2+) signalling and membrane functions. By forming networks on the membrane surface, annexins can function as organizers of membrane domains and membrane-recruitment platforms for proteins with which they interact. These and related properties enable annexins to participate in several otherwise unrelated events that range from membrane dynamics to cell differentiation and migration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Annexins / chemistry
  • Annexins / genetics
  • Annexins / metabolism*
  • Biological Transport / physiology
  • Calcium / metabolism
  • Calcium Signaling / physiology*
  • Cell Membrane / metabolism*
  • Humans
  • Ion Channels / metabolism
  • Microscopy, Atomic Force
  • Models, Molecular
  • Protein Structure, Tertiary


  • Actins
  • Annexins
  • Ion Channels
  • Calcium