Eph receptor signalling casts a wide net on cell behaviour

Nat Rev Mol Cell Biol. 2005 Jun;6(6):462-75. doi: 10.1038/nrm1662.


Eph receptor tyrosine kinases mould the behaviour of many cell types by binding membrane-anchored ligands, ephrins, at sites of cell-cell contact. Eph signals affect both of the contacting cells and can produce diverse biological responses. New models explain how quantitative variations in the densities and signalling abilities of Eph receptors and ephrins could account for the different effects that are elicited on axon guidance, cell adhesion and cell migration during development, homeostasis and disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion
  • Cell Differentiation
  • Cell Membrane / chemistry
  • Cell Membrane / metabolism
  • Cell Movement
  • Cell Physiological Phenomena*
  • Cell Proliferation
  • Ephrins / chemistry
  • Ephrins / genetics
  • Ephrins / metabolism
  • Humans
  • Neurons / cytology
  • Neurons / metabolism
  • Protein Binding
  • Receptor, EphA1 / chemistry
  • Receptor, EphA1 / genetics
  • Receptor, EphA1 / metabolism*
  • Signal Transduction / physiology*


  • Ephrins
  • Receptor, EphA1