CLIPs and CLASPs and cellular dynamics

Nat Rev Mol Cell Biol. 2005 Jun;6(6):487-98. doi: 10.1038/nrm1664.


The dynamic properties of microtubules are regulated by plus-end tracking proteins (+TIPs), which associate with the distal ends of microtubules. Among the +TIPs are cytoplasmic linker proteins (CLIPs), which promote microtubule growth and regulate dynein-dynactin localization, and CLIP-associating proteins (CLASPs), which stabilize specific subsets of microtubules on reception of signalling cues. CLIPs and CLASPs interact and cooperate to direct the microtubule network, thereby regulating cellular asymmetry.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Polarity
  • Cytoskeleton / metabolism*
  • Humans
  • Microtubule-Associated Proteins / chemistry
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / metabolism*
  • Microtubules / chemistry
  • Microtubules / metabolism*
  • Models, Molecular
  • Molecular Sequence Data
  • Neoplasm Proteins
  • Neurons / cytology
  • Neurons / metabolism
  • Sequence Alignment


  • CLASP1 protein, human
  • EB1 microtubule binding proteins
  • Microtubule-Associated Proteins
  • Neoplasm Proteins
  • cytoplasmic linker protein 170