Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei

Biotechnol Lett. 2005 Apr;27(7):483-7. doi: 10.1007/s10529-005-2225-8.

Abstract

Beta-glucans were prepared from Agaricus blazei Murill by repeated extraction with hot water. The average molecular weights of beta-glucans were 30-50 kDa by gel filtration chromatography. Oligosaccharides (AO), derived from hydrolyzing beta-glucans with an endo-beta-(1-->6)-glucanase from Bacillus megaterium, were mainly di- and tri-saccharides. Though beta-glucans and AO both showed anti-hyperglycemic, anti-hypertriglyceridemic, anti-hypercholesterolemic, and anti-arteriosclerotic activity indicating overall anti-diabetic activity in diabetic rats, AO had about twice the activity of beta-glucans with respect to anti-diabetic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricus / metabolism*
  • Animals
  • Bacillus megaterium / enzymology
  • Cholesterol / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Disaccharides / chemistry
  • Disaccharides / isolation & purification
  • Disaccharides / metabolism
  • Disaccharides / pharmacology
  • Glycoside Hydrolases / metabolism
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / isolation & purification
  • Hypoglycemic Agents / metabolism
  • Hypoglycemic Agents / pharmacology*
  • Hypolipidemic Agents / chemistry
  • Hypolipidemic Agents / isolation & purification
  • Hypolipidemic Agents / metabolism
  • Hypolipidemic Agents / pharmacology
  • Insulin / blood
  • Insulin / metabolism
  • Insulin Secretion
  • Molecular Weight
  • Oligosaccharides / chemistry
  • Oligosaccharides / isolation & purification
  • Oligosaccharides / metabolism
  • Oligosaccharides / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Triglycerides / blood
  • Trisaccharides / chemistry
  • Trisaccharides / isolation & purification
  • Trisaccharides / metabolism
  • Trisaccharides / pharmacology
  • beta-Glucans / chemistry
  • beta-Glucans / isolation & purification
  • beta-Glucans / metabolism
  • beta-Glucans / pharmacology*

Substances

  • Disaccharides
  • Hypoglycemic Agents
  • Hypolipidemic Agents
  • Insulin
  • Oligosaccharides
  • Triglycerides
  • Trisaccharides
  • beta-Glucans
  • Cholesterol
  • Glycoside Hydrolases
  • endo-1,6-beta-glucanase