Abstract
Beta-glucans were prepared from Agaricus blazei Murill by repeated extraction with hot water. The average molecular weights of beta-glucans were 30-50 kDa by gel filtration chromatography. Oligosaccharides (AO), derived from hydrolyzing beta-glucans with an endo-beta-(1-->6)-glucanase from Bacillus megaterium, were mainly di- and tri-saccharides. Though beta-glucans and AO both showed anti-hyperglycemic, anti-hypertriglyceridemic, anti-hypercholesterolemic, and anti-arteriosclerotic activity indicating overall anti-diabetic activity in diabetic rats, AO had about twice the activity of beta-glucans with respect to anti-diabetic activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricus / metabolism*
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Animals
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Bacillus megaterium / enzymology
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Cholesterol / blood
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Diabetes Mellitus, Experimental / drug therapy*
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Disaccharides / chemistry
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Disaccharides / isolation & purification
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Disaccharides / metabolism
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Disaccharides / pharmacology
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Glycoside Hydrolases / metabolism
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / metabolism
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Hypoglycemic Agents / pharmacology*
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / isolation & purification
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Hypolipidemic Agents / metabolism
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Hypolipidemic Agents / pharmacology
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Insulin / blood
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Insulin / metabolism
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Insulin Secretion
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Molecular Weight
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Oligosaccharides / chemistry
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Oligosaccharides / isolation & purification
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Oligosaccharides / metabolism
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Oligosaccharides / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Triglycerides / blood
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Trisaccharides / chemistry
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Trisaccharides / isolation & purification
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Trisaccharides / metabolism
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Trisaccharides / pharmacology
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beta-Glucans / chemistry
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beta-Glucans / isolation & purification
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beta-Glucans / metabolism
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beta-Glucans / pharmacology*
Substances
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Disaccharides
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Hypoglycemic Agents
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Hypolipidemic Agents
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Insulin
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Oligosaccharides
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Triglycerides
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Trisaccharides
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beta-Glucans
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Cholesterol
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Glycoside Hydrolases
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endo-1,6-beta-glucanase