Outcome of heart-lung and bilateral sequential lung transplantation for cystic fibrosis: a UK national study

Eur Respir J. 2005 Jun;25(6):964-9. doi: 10.1183/09031936.05.00073004.


Cystic fibrosis (CF) patients requiring transplantation for respiratory failure may undergo either heart-lung (HLT) or bilateral sequential lung (BSLT) transplantation. The choice of operation varies between surgeons, centres and countries. The current authors investigated whether operation type influenced outcome in adult CF patients transplanted in the UK between July 1995 and June 2002. Propensity scores for receipt of BSLT versus HLT were derived using logistic regression. Cox regression was used to compare survival. In total, 88 BSLTs and 93 HLTs were identified. Patient characteristics were similar overall, but HLT recipients were more likely to be on long-term oxygen therapy and to have had prior resuscitation. There were 72 deaths (29 BSLT and 43 HLT) within 4 yrs. There was a trend towards higher unadjusted survival following BSLT, but, after adjustment, no difference was found (hazard ratio = 0.77; 95% confidence interval 0.29-2.06). Time to the first rejection episode and infection rates were also similar. A total of 82% of hearts from HLT recipients were used as domino heart transplants. In conclusion, after adjusting for comorbidity, donor factors and ischaemia time, it was found that heart-lung and bilateral sequential lung transplantation achieved a similar outcome. The use of domino heart transplantation ameliorated the impact of heart-lung transplantation on total organ availability.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • Cystic Fibrosis / surgery*
  • Female
  • Graft Rejection / epidemiology
  • Heart Transplantation / statistics & numerical data
  • Heart-Lung Transplantation / statistics & numerical data*
  • Humans
  • Infections / epidemiology
  • Lung Transplantation / statistics & numerical data*
  • Male
  • Prospective Studies
  • Respiratory Function Tests / statistics & numerical data
  • Survival Analysis
  • Treatment Outcome
  • United Kingdom / epidemiology
  • Waiting Lists