Vigintiphobia revisited

Pediatrics. 2005 Jun;115(6):1747-53. doi: 10.1542/peds.2004-1748.

Abstract

In this review the historical tenets and evidence-based clinical research in support of a bilirubin exchange threshold of >20 mg/dL for the healthy term neonate are revisited. In addition, a hypothesis is ventured that recent cases of kernicterus are related in part to changes in population factors coupled with genetic predispositions that have unmasked an unappreciated potential for marked neonatal hyperbilirubinemia.

Publication types

  • Review

MeSH terms

  • Anemia, Hemolytic / blood
  • Anemia, Hemolytic / complications
  • Anemia, Hemolytic / therapy
  • Bilirubin / blood*
  • Breast Feeding / adverse effects
  • Crigler-Najjar Syndrome / complications
  • Crigler-Najjar Syndrome / genetics
  • Dehydration / complications
  • Diagnosis, Differential
  • Erythroblastosis, Fetal / blood
  • Erythroblastosis, Fetal / complications
  • Erythroblastosis, Fetal / genetics
  • Erythroblastosis, Fetal / therapy
  • Exchange Transfusion, Whole Blood*
  • Genetic Predisposition to Disease
  • Gilbert Disease / complications
  • Gilbert Disease / genetics
  • Glucuronosyltransferase / deficiency
  • Glucuronosyltransferase / genetics
  • Humans
  • Iatrogenic Disease / prevention & control
  • Incidence
  • Infant, Newborn
  • Jaundice, Neonatal / blood*
  • Jaundice, Neonatal / complications
  • Jaundice, Neonatal / diagnosis
  • Jaundice, Neonatal / genetics
  • Jaundice, Neonatal / radiotherapy
  • Jaundice, Neonatal / therapy
  • Kernicterus / blood*
  • Kernicterus / epidemiology
  • Kernicterus / etiology
  • Kernicterus / prevention & control
  • Mutation
  • Practice Guidelines as Topic
  • Reference Values
  • Rh Isoimmunization
  • Ultraviolet Therapy
  • United States / epidemiology

Substances

  • UGT1A1 enzyme
  • Glucuronosyltransferase
  • Bilirubin