A pathophysiological paradigm for the therapy of psychiatric disease

Nat Rev Drug Discov. 2005 Jun;4(6):467-76. doi: 10.1038/nrd1753.


Despite enormous progress in fundamental knowledge in neuroscience, no revolutionary therapies in psychiatry (and neurology) have emerged in the past ten years. Most drugs alleviate symptoms, rather than restoring the 'set point' of brain function from a pathological position to a more normal one. We propose a hypothesis-driven, systems-level approach to drug discovery and development that is based on pathophysiology and which uses new animal models.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Mental Disorders / drug therapy*
  • Mental Disorders / physiopathology*
  • Psychotropic Drugs / chemical synthesis
  • Psychotropic Drugs / pharmacology
  • Psychotropic Drugs / therapeutic use*


  • Psychotropic Drugs