Genomic islands in the Corynebacterium efficiens genome

Appl Environ Microbiol. 2005 Jun;71(6):3126-30. doi: 10.1128/AEM.71.6.3126-3130.2005.


Corynebacterium efficiens is a gram-positive nonpathogenic bacterium which can grow and produce glutamate at 40 degrees C or above. By using the cumulative GC profile method, we have identified four genomic islands which have many unifying genomic island-specific features in the C. efficiens genome. The presence of the gene encoding an aspartate kinase in a genomic island helps explain the unexpected low thermal stability of this enzyme; i.e., the adaptive mutations have not occurred extensively due to the recent horizontal gene transfer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspartate Kinase / genetics
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Base Composition
  • Base Sequence
  • Corynebacterium / enzymology*
  • Corynebacterium / genetics
  • Enzyme Stability
  • Genome, Bacterial*
  • Genomic Islands* / genetics
  • Hot Temperature
  • Molecular Sequence Data


  • Bacterial Proteins
  • Aspartate Kinase