Clinical, virologic and immunologic profiles of a young infant with severe acute respiratory syndrome

Pediatr Infect Dis J. 2005 Jun;24(6):567-8. doi: 10.1097/01.inf.0000164703.61282.3b.


The clinical findings, plasma viral load, cytokines and chemokines of a 4-month-old infant with severe acute respiratory syndrome (SARS) were assessed at different phases of the disease. Ribavirin failed to inhibit SARS coronavirus (SARS-CoV) replication. One-step real time reverse transcription-polymerase chain reaction for plasma SARS-CoV RNA quantification was useful for early diagnosis and monitoring viremia.

Publication types

  • Case Reports

MeSH terms

  • Cytokines / blood*
  • Female
  • Humans
  • Infant
  • RNA, Viral / blood
  • SARS Virus* / genetics
  • SARS Virus* / isolation & purification
  • SARS Virus* / physiology
  • Severe Acute Respiratory Syndrome* / immunology
  • Severe Acute Respiratory Syndrome* / physiopathology
  • Severe Acute Respiratory Syndrome* / virology
  • Time Factors
  • Viral Load*


  • Cytokines
  • RNA, Viral