Antioxidant activity of DHC-1, an herbal formulation, in experimentally-induced cardiac and renal damage

Phytother Res. 2005 Mar;19(3):216-21. doi: 10.1002/ptr.1659.


DHC-1, an herbal formulation derived from the popular plants Bacopa monniera, Emblica officinalis, Glycyrrhiza glabra, Mangifera indica and Syzygium aromaticum was studied for its antioxidant activity. The protective effect of DHC-1 in isoproterenol-induced myocardial infarction and cisplatin-induced renal damage were studied. A significant reduction in the serum markers of heart and kidney damage and the extent of lipid peroxidation with a concomitant increase in the enzymatic (SOD and CAT) and non-enzymatic antioxidants (reduced glutathione) were observed in DHC-1 pretreated animals compared with the isoproterenol or cisplatin alone treated animals. Thus it can be concluded that DHC-1 possesses a protective effect against both damaged heart and kidneys in rats. This beneficial effect may be attributed, at least in part, to its antioxidant activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use
  • Bacopa
  • Cisplatin
  • Female
  • Glycyrrhiza
  • Isoproterenol
  • Kidney Diseases / chemically induced
  • Kidney Diseases / prevention & control*
  • Male
  • Mangifera
  • Myocardial Infarction / chemically induced
  • Myocardial Infarction / prevention & control*
  • Phyllanthus emblica
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plants, Medicinal*
  • Protective Agents / administration & dosage
  • Protective Agents / pharmacology*
  • Protective Agents / therapeutic use
  • Rats
  • Rats, Wistar
  • Syzygium


  • Antioxidants
  • DHC-1, herbal formulation
  • Plant Extracts
  • Protective Agents
  • Isoproterenol
  • Cisplatin