The Binkhorst Medal Lecture. Biologic relationship between poly(methyl methacrylate) intraocular lenses and uveal tissue

J Cataract Refract Surg. 1992 May;18(3):219-31. doi: 10.1016/s0886-3350(13)80897-8.


Implantation of a poly(methyl methacrylate) (PMMA) intraocular lens (IOL) after cataract surgery is associated with breakdown of the blood-ocular barrier and a foreign body inflammatory response. Although the material is biocompatible, it is not inert. The history of PMMA IOL implantation has reflected mechanical, chemical, and immunological interactions between the IOL and ocular tissues. The common link in these events is instability of the blood-ocular barrier. In this lecture, I discuss the nature of these interactions and present evidence that currently investigated methods of surface modification and capsular bag IOL implantation are effective in stabilizing the blood-ocular barrier.

Publication types

  • Review

MeSH terms

  • Animals
  • Biocompatible Materials
  • Biological Transport, Active
  • Blood-Retinal Barrier
  • Cataract Extraction
  • Endophthalmitis / etiology
  • Foreign-Body Reaction / etiology*
  • Humans
  • Lenses, Intraocular / adverse effects*
  • Methylmethacrylates / adverse effects*
  • Surface Properties
  • Uveal Diseases / etiology


  • Biocompatible Materials
  • Methylmethacrylates