Redox redux: revisiting PTPs and the control of cell signaling

Cell. 2005 Jun 3;121(5):667-70. doi: 10.1016/j.cell.2005.05.016.


The architecture of the active site of members of the protein tyrosine phosphatase (PTP) superfamily renders these enzymes sensitive to reversible oxidation and inactivation. The importance of reversible oxidation of PTP superfamily members in controlling the signal output following an extracellular stimulus is discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • JNK Mitogen-Activated Protein Kinases / metabolism
  • Macrophages / enzymology
  • Oxidation-Reduction
  • Protein Tyrosine Phosphatases / metabolism*
  • Reactive Oxygen Species / metabolism
  • Receptors, Antigen, B-Cell / metabolism
  • Signal Transduction / physiology*
  • Tumor Necrosis Factor-alpha / metabolism


  • Reactive Oxygen Species
  • Receptors, Antigen, B-Cell
  • Tumor Necrosis Factor-alpha
  • JNK Mitogen-Activated Protein Kinases
  • Protein Tyrosine Phosphatases