Polarity proteins in axon specification and synaptogenesis

Dev Cell. 2005 Jun;8(6):803-16. doi: 10.1016/j.devcel.2005.05.007.


The neuron is a prime example of a highly polarized cell. It is becoming clear that conserved protein complexes, which have been shown to regulate polarity in such diverse systems as the C. elegans zygote and mammalian epithelia, are also required for neuronal polarization. This review considers the role of these polarity proteins in axon specification and synaptogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Axons / metabolism*
  • Body Patterning
  • Cell Polarity / physiology*
  • Models, Neurological
  • Neurons / metabolism
  • Proteins / classification
  • Proteins / metabolism*
  • Signal Transduction / physiology
  • Synapses / physiology*


  • Proteins