Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task

Behav Brain Res. 2005 Aug 30;163(1):136-40. doi: 10.1016/j.bbr.2005.04.014.


This work aimed to evaluate further the role of 5-HT7 receptors during memory formation in an autoshaping Pavlovian/instrumental learning task. Post-training administration of the potential 5-HT7 receptor agonist AS 19 or antagonist SB-269970 enhanced memory formation or had no effect, respectively. The AS 19 facilitatory effect was reversed by SB-269970, but not by the selective 5-HT1A antagonist WAY100635. Amnesia induced by scopolamine (cholinergic antagonist) or dizocilpine (NMDA antagonist) was also reversed by AS 19. Certainly, reservations regarding the selectivity of AS 19 for 5-HT7 and other 5-HT receptors in vivo are noteworthy and, therefore, its validity for use in animal models as a pharmacological tool. Having mentioned that, it should be noticed that together these data are providing further support to the notion of the 5-HT7 receptors role in memory formation. Importantly, this 5-HT7 receptor agonist AS 19 appears to represent a step forward respect to the notion that potent and selective 5-HT7 receptor agonists can be useful in the treatment of dysfunctional memory in aged-related decline and Alzheimer's disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Association Learning / drug effects*
  • Conditioning, Classical / drug effects*
  • Male
  • Memory / drug effects*
  • Phenols / pharmacology
  • Piperazines / pharmacology
  • Pyrazoles / pharmacology*
  • Pyridines / pharmacology
  • Rats
  • Rats, Wistar
  • Receptors, Serotonin / drug effects*
  • Serotonin Receptor Agonists / pharmacology*
  • Sulfonamides / pharmacology
  • Tetrahydronaphthalenes / pharmacology*


  • AS 19 compound
  • Phenols
  • Piperazines
  • Pyrazoles
  • Pyridines
  • Receptors, Serotonin
  • SB 269970
  • Serotonin Receptor Agonists
  • Sulfonamides
  • Tetrahydronaphthalenes
  • serotonin 7 receptor
  • N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide