Modulation of radiation-induced alteration in the antioxidant status of mice by naringin

Life Sci. 2005 Jul 1;77(7):780-94. doi: 10.1016/j.lfs.2005.01.015. Epub 2005 Apr 21.


The alteration in the antioxidant status and lipid peroxidation was investigated in Swiss albino mice treated with 2 mg/kg b.wt. naringin, a citrus flavoglycoside, before exposure to 0.5, 1, 2, 3, and 4 Gy gamma radiation. Lipid peroxidation, glutathione, glutathione peroxidase, catalase and superoxide dismutase were determined in the liver and small intestine of mice treated or not with naringin at 0.5, 1, 2, 4 and 8 h post-irradiation. Whole-body irradiation of mice caused a dose-dependent elevation in the lipid peroxidation while a dose-dependent depletion was observed for glutathione, glutathione peroxidase, superoxide dismutase and catalase in both liver as well as small intestine. Treatment of mice with 2 mg/kg b. wt. naringin inhibited the radiation-induced elevation in the lipid peroxidation as well as depletion of glutathione, glutathione peroxidase, superoxide dismutase and catalase in liver and small intestine. Radiation-induced lipid peroxidation increased with time, which was greatest at 2 h post-irradiation and declined thereafter in the liver and small intestine. Similarly, a maximum decline in the glutathione glutathione peroxidase, and superoxide dismutase was observed at 1 h, while catalase showed a maximum decline at 2 h post-irradiation. Our study demonstrates that naringin protects mouse liver and intestine against the radiation-induced damage by elevating the antioxidant status and reducing the lipid peroxidation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalase / metabolism
  • Dose-Response Relationship, Drug
  • Dose-Response Relationship, Radiation
  • Enzyme Activation / drug effects
  • Enzyme Activation / radiation effects
  • Flavanones / pharmacology*
  • Gamma Rays*
  • Glutathione / metabolism
  • Glutathione Peroxidase / metabolism
  • Intestine, Small / drug effects*
  • Intestine, Small / radiation effects
  • Lipid Peroxidation / drug effects*
  • Lipid Peroxidation / radiation effects
  • Liver / drug effects*
  • Liver / radiation effects
  • Mice
  • Superoxide Dismutase / metabolism
  • Time Factors


  • Flavanones
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione
  • naringin