CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa

Nat Immunol. 2005 Jul;6(7):698-706. doi: 10.1038/ni1212. Epub 2005 Jun 5.


One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Antigens, CD / immunology*
  • CD27 Ligand
  • Cell Differentiation / immunology
  • Flow Cytometry
  • Immunohistochemistry
  • Intestinal Mucosa / cytology
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / microbiology
  • Listeria monocytogenes / immunology*
  • Listeriosis / immunology*
  • Listeriosis / pathology
  • Lymphocyte Activation / immunology
  • Membrane Proteins / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Phagocytosis / immunology
  • Specific Pathogen-Free Organisms
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 / immunology


  • Antigens, CD
  • CD27 Ligand
  • Cd70 protein, mouse
  • Membrane Proteins
  • Tumor Necrosis Factor Receptor Superfamily, Member 7