Fetal hemangiopericytoma with an associated cerebral anomaly

Ultrasound Obstet Gynecol. 2005 Jul;26(1):81-5. doi: 10.1002/uog.1913.


We report the first case of infantile hemangiopericytoma explored prenatally by fetal ultrasonography and magnetic resonance imaging (MRI). It was associated with a developmental cerebral anomaly identified on MRI. The largest lesions of the multifocal hemangiopericytoma were located in the soft tissue adjacent to the left temporal bone, and smaller lesions were found in the lumbar area and in the retroperitoneum. MRI showed no connection between the tumor and the fetal brain but there was anomalous cerebral gyration in the region and the Sylvian fissure beneath the tumor was enlarged. The pregnancy was terminated because of the severe brain anomalies and postmortem examination confirmed the prenatal findings. Microscopic analysis of the tumor tissue showed branching vessels which are typical of hemangiopericytoma. The lesions in our case occurred in association with macrosomia with visceromegaly detected at autopsy, suggesting a possible role of tumor suppressor genes.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abnormalities, Multiple / diagnostic imaging*
  • Abnormalities, Multiple / pathology
  • Abortion, Therapeutic
  • Brain / abnormalities*
  • Brain Neoplasms / complications
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / pathology
  • Echoencephalography
  • Female
  • Fetal Macrosomia / pathology
  • Hemangiopericytoma / complications
  • Hemangiopericytoma / diagnostic imaging*
  • Hemangiopericytoma / pathology
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Pregnancy
  • Pregnancy Trimester, Third
  • Ultrasonography, Prenatal / methods*
  • Viscera / abnormalities