DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside

Ahmet C Gören; Bing-Nan Zhou; Gülaçti Topçu; Gamze Kökdil; David G I Kingston

doi:10.1080/14786410412331272095

DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside

Nat Prod Res. 2005 Jul;19(5):457-60. doi: 10.1080/14786410412331272095.

Authors

Ahmet C Gören¹, Bing-Nan Zhou, Gülaçti Topçu, Gamze Kökdil, David G I Kingston

Affiliation

¹ TUBITAK, Ulusal Metroloji Enstitüsü, Group of Chemistry, PO Box 54, 41470, Gebze-Kocaeli, Turkey. ahmet.goren@ume.tubitak.gov.tr

PMID: 15938192
DOI: 10.1080/14786410412331272095

Abstract

An iridoid glucoside reptoside (1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A. postii two known triterpenic compounds ursolic acid, alpha-amyrin and two steroidal compounds (24S)-24-ethylcholesta-5,25-dien-3beta-ol and beta-sitosterol were isolated. Their structures were elucidated based on 1D and 2D NMR techniques and mass data.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Ajuga / chemistry*
DNA Damage*
Iridoids / chemistry*
Iridoids / toxicity
Oleanolic Acid / analogs & derivatives
Oleanolic Acid / chemistry
Plant Extracts / toxicity
Sitosterols / chemistry
Sterols / chemistry
Triterpenes / chemistry
Ursolic Acid

Substances

(24S)-24-ethylcholesta-5,25-dien-3beta-ol
Iridoids
Plant Extracts
Sitosterols
Sterols
Triterpenes
reptoside
gamma-sitosterol
Oleanolic Acid
beta-amyrin