A randomized, double-blind, placebo-controlled study on the clinical efficacy of oral treatment with DermaVite on ageing symptoms of the skin

J Int Med Res. May-Jun 2005;33(3):267-72. doi: 10.1177/147323000503300301.

Abstract

In this double-blind, placebo-controlled study, 40 women with ageing symptoms of the skin were randomized to receive DermaVite, a new preparation containing marine proteins, alpha-lipoic acid, pine bark extract, vitamins and minerals (n = 20), or placebo (n = 20) twice daily for 6 months. Objective measurements of skin thickness and elasticity, together with subjective clinical assessments of various parameters (fine wrinkles, coarse wrinkles, tactile roughness and teleangiectasia) were used to evaluate changes after 2, 4 and 6 months' treatment. Self-evaluations were also made by the study participants. There was a significant improvement in skin quality in both objective and subjective parameters after treatment with Dermavite compared with placebo. Participants' self-evaluations also showed a statistically significant difference in favour of the active treatment. The treatment was very well tolerated. Based on this efficacy and tolerability study, DermaVite can be considered a suitable therapy for ageing symptoms of the skin.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Aging*
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Humans
  • Middle Aged
  • Pinus
  • Placebos
  • Plant Bark
  • Plant Extracts / administration & dosage*
  • Plant Extracts / pharmacology
  • Proteins / administration & dosage*
  • Proteins / pharmacology
  • Skin / drug effects*
  • Skin / pathology
  • Skin Aging / drug effects*
  • Thioctic Acid / administration & dosage*
  • Thioctic Acid / pharmacology
  • Time Factors

Substances

  • Placebos
  • Plant Extracts
  • Proteins
  • Thioctic Acid