Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance
- PMID: 15940739
- DOI: 10.1002/chem.200500320
Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance
Abstract
Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci. They are produced by a strain of Streptomyces tendae, isolated from an ancient cave. The structures of the cervimycins were determined by performing extensive NMR and chemical degradation studies. All cervimycins have a common tetracyclic polyketide core that is substituted with unusual di- and tetrasaccharide chains, composed exclusively of trideoxysugars; however, they differ in the acetyl and carbamoyl ring substituent and in the highly unusual terminal methylmalonyl and dimethylmalonyl residues.
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