[Phospholipid membrane modification as a protection factor of the myocardium during stress injury]

A M Shysh; T V Kukoba; L V Tumanovs'ka; O O Moĭbenko

[Phospholipid membrane modification as a protection factor of the myocardium during stress injury]

Fiziol Zh (1994). 2005;51(2):17-23.

[Article in Ukrainian]

Authors

A M Shysh¹, T V Kukoba, L V Tumanovs'ka, O O Moĭbenko

Affiliation

¹ O. O. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv.

PMID: 15943227

Abstract

In experiments on the isolated rat hearts we investigated the influence of phospholipid membrane modification by omega-3 polyunsaturated fatty acids (PUFAs) on the heart reactivity to adrenergic influences, myocardial ultrastructure and peroxidation processes under the immobilization stress. It was shown that omega-3 PUFAs reduced ultrastructural changes in the heart, limited lipid peroxidation and attenuated inotropic response of the heart to exogenous norepinephrine.

Publication types

English Abstract

MeSH terms

Acute Disease
Animals
Cell Membrane / metabolism*
Disease Models, Animal
Fatty Acids, Omega-3 / pharmacology
Free Radicals / metabolism
In Vitro Techniques
Lipid Peroxidation
Male
Microscopy, Electron
Myocardial Contraction / drug effects
Myocardial Contraction / physiology*
Myocardium / metabolism*
Myocardium / ultrastructure
Norepinephrine / pharmacology
Phospholipids / metabolism*
Rats
Restraint, Physical
Stress, Psychological / metabolism*
Stress, Psychological / physiopathology

Substances

Fatty Acids, Omega-3
Free Radicals
Phospholipids
Norepinephrine