Is metoclopramide an alternative to tramadol in management of post-operative pain? An experimental study

J Vet Med A Physiol Pathol Clin Med. 2005 Jun;52(5):249-53. doi: 10.1111/j.1439-0442.2005.00719.x.


In this study, metoclopramide was compared with other pharmacological agents for preventing post-operative pain. Sixty Sprague-Dawley male rats, weighing 310-345 g were included in the study; 1 cm surgical incision, including skin, facia, and muscle was made to the plantar surface of rear foot of all anaesthetized rats. Rats were randomized into four groups. In group 1 (group S) 2 cm3 saline, in group 2 (group M) 2 cm3 metoclopramide (5 mg/kg) in group 3 (group T) 2 cm3 tramadol (45 mg/kg), in group 4 (group M+T) half doses of group M and group T was given intraperitoneally. Post-operative pain was assessed after 2 h, first and second days of incision. Post-operative pain scores were found to be significantly lower in group M, group T and group M+T when compared with the control group. But there was no significant difference between these groups. We concluded that metoclopramide, with low cost, fewer side-effects and being significantly effective for preventing post-operative pain, can be an alternative to tramadol.

Publication types

  • Clinical Conference

MeSH terms

  • Analgesics, Opioid / administration & dosage
  • Analgesics, Opioid / therapeutic use
  • Animals
  • Dopamine Antagonists / administration & dosage
  • Dopamine Antagonists / therapeutic use*
  • Male
  • Metoclopramide / administration & dosage
  • Metoclopramide / therapeutic use*
  • Pain Measurement
  • Pain, Postoperative / prevention & control*
  • Rats
  • Rats, Sprague-Dawley
  • Tramadol / administration & dosage
  • Tramadol / therapeutic use
  • Treatment Outcome


  • Analgesics, Opioid
  • Dopamine Antagonists
  • Tramadol
  • Metoclopramide