Linear motifs: evolutionary interaction switches

FEBS Lett. 2005 Jun 13;579(15):3342-5. doi: 10.1016/j.febslet.2005.04.005. Epub 2005 Apr 18.


Linear motifs are short sequence patterns associated with a particular function. They differ fundamentally from longer, globular protein domains in terms of their binding affinities, evolution and in how they are found experimentally or computationally. In this Minireview, we discuss various aspects of these critically important functional regions.

Publication types

  • Review

MeSH terms

  • Amino Acid Motifs*
  • Amino Acid Sequence
  • Animals
  • Evolution, Molecular*
  • Humans
  • Molecular Sequence Data
  • Nucleic Acids / chemistry
  • Nucleic Acids / genetics
  • Nucleic Acids / metabolism


  • Nucleic Acids