Dendritic spine geometry: functional implication and regulation

Neuron. 2005 May 19;46(4):529-32. doi: 10.1016/j.neuron.2005.05.006.


Dendritic spines are tiny protrusions on dendritic shafts where most excitatory synapses are located. Recent advances in imaging technologies have given us great insight into the function of spines as biochemical compartments. Here we review recent evidence suggesting that the geometry of dendritic spines controls postsynaptic calcium signaling and is bidirectionally regulated during synaptic plasticity.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Dendritic Spines / physiology*
  • Models, Neurological
  • Neuronal Plasticity / physiology*
  • Receptors, Glutamate / classification
  • Receptors, Glutamate / physiology
  • Signal Transduction / physiology*


  • Receptors, Glutamate
  • Calcium