doi: 10.1093/hmg/ddi210.
Epub 2005 Jun 8.
Foxl2 is required for commitment to ovary differentiation
Affiliations
- PMID: 15944199
- DOI: 10.1093/hmg/ddi210
Item in Clipboard
Foxl2 is required for commitment to ovary differentiation
Hum Mol Genet.
.
Abstract
Genetic control of female sex differentiation from a bipotential gonad in mammals is poorly understood. We find that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination. Pivotal Foxl2 action thus represses the male gene pathway at several stages of female gonadal differentiation. This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.
Similar articles
-
Determination and stability of sex.Bioessays. 2007 Jan;29(1):15-25. doi: 10.1002/bies.20515. Bioessays. 2007. PMID: 17187356 Review.
-
Determination and stability of gonadal sex.J Androl. 2010 Jan-Feb;31(1):16-25. doi: 10.2164/jandrol.109.008201. Epub 2009 Oct 29. J Androl. 2010. PMID: 19875493 Free PMC article. Review.
-
Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads.Hum Mol Genet. 2018 Dec 15;27(24):4273-4287. doi: 10.1093/hmg/ddy312. Hum Mol Genet. 2018. PMID: 30212841 Free PMC article.
-
The forkhead transcription factor FOXL2 is expressed in somatic cells of the human ovary prior to follicle formation.Mol Hum Reprod. 2009 Dec;15(12):771-7. doi: 10.1093/molehr/gap065. Epub 2009 Aug 25. Mol Hum Reprod. 2009. PMID: 19706741 Free PMC article.
-
Foxl2 functions in sex determination and histogenesis throughout mouse ovary development.BMC Dev Biol. 2009 Jun 18;9:36. doi: 10.1186/1471-213X-9-36. BMC Dev Biol. 2009. PMID: 19538736 Free PMC article.
Cited by
-
Sexual determination in zebrafish.Cell Mol Life Sci. 2021 Dec 22;79(1):8. doi: 10.1007/s00018-021-04066-4. Cell Mol Life Sci. 2021. PMID: 34936027 Free PMC article. Review.
-
Morphometric analyses and gene expression related to germ cells, gonadal ridge epithelial-like cells and granulosa cells during development of the bovine fetal ovary.PLoS One. 2019 Mar 22;14(3):e0214130. doi: 10.1371/journal.pone.0214130. eCollection 2019. PLoS One. 2019. PMID: 30901367 Free PMC article.
-
Cocktails of NSAIDs and 17α Ethinylestradiol at Environmentally Relevant Doses in Drinking Water Alter Puberty Onset in Mice Intergenerationally.Int J Mol Sci. 2023 Mar 20;24(6):5890. doi: 10.3390/ijms24065890. Int J Mol Sci. 2023. PMID: 36982971 Free PMC article.
-
Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster.Nat Commun. 2024 May 7;15(1):3809. doi: 10.1038/s41467-024-47658-x. Nat Commun. 2024. PMID: 38714644 Free PMC article.
-
Primary sex determination of placental mammals: a modelling study uncovers dynamical developmental constraints in the formation of Sertoli and granulosa cells.BMC Syst Biol. 2016 May 26;10(1):37. doi: 10.1186/s12918-016-0282-3. BMC Syst Biol. 2016. PMID: 27229461 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
