Antigenic profile of human bronchial gland

Histol Histopathol. 2005 Jul;20(3):865-70. doi: 10.14670/HH-20.865.


Bronchial glands have been regarded as modified salivary glands. It is well known that there no previous reviews concerning the antigenic profile of the bronchial wall. The aim of this study is a systematic survey of the antigenic profile and to describe the histology of normal human bronchial glands. Six formalin-fixed, paraffin-embedded surgical specimens were studied using a panel of 22 polyclonal and monoclonal antibodies by the avidin-biotin-peroxidase method. Bronchial glands disclosed a tubuloacinar structure. The smallest ducts intercalated originated from a cluster of secretory acini and converge to form an excretory duct. No striated duct was observed. Acinar united is composed by mucous, serous and mixed units. Myoepithelial cells are found in relation to the intercalated ducts and secretory acinis. Secretory cells of bronchial glands reacted strongly with cytokeratin AE1 and moderately for CK7, CK18. Additionally, serous acinar cells reacted with AE3, CK19, CK5/6/8/18, CK8/18/19, and Leu7. Myoepithelial cells reacted strongly with a-smooth muscle actin, CD10 and CK34betaE12. Ductal system cells differed from acinar secretory cells in expressing CK34betaE12 and HSP27. In conclusion, the detailed knowledge of the immunohistochemical reactivities of normal cell types of normal human bronchial glands will prove useful in studies of bronchial pathology, especially of neoplastic processes.

MeSH terms

  • Actins / analysis
  • Antigens / analysis
  • Biomarkers / analysis*
  • Bronchi / chemistry*
  • Bronchi / cytology
  • Bronchi / immunology
  • Exocrine Glands / chemistry
  • Exocrine Glands / immunology
  • HSP27 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins / analysis
  • Heat-Shock Proteins / analysis
  • Humans
  • Immunohistochemistry
  • Intermediate Filaments / metabolism
  • Keratin-7
  • Keratins / analysis
  • Molecular Chaperones
  • Muscle, Smooth / chemistry
  • Neoplasm Proteins / analysis
  • Neprilysin / analysis
  • S100 Proteins / analysis


  • Actins
  • Antigens
  • Biomarkers
  • HSP27 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins
  • HSPB1 protein, human
  • Heat-Shock Proteins
  • KRT7 protein, human
  • Keratin-7
  • Molecular Chaperones
  • Neoplasm Proteins
  • S100 Proteins
  • Keratins
  • Neprilysin