Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62

Immunology. 2005 Jul;115(3):296-304. doi: 10.1111/j.1365-2567.2005.02167.x.


Secretion of immunomodulatory molecules is a key strategy employed by pathogens to enable their survival in host organisms. For example, arthropod-transmitted filarial nematodes, which achieve longevity within the infected host by suppressing and modulating the host immune response, produce excretory-secretory (ES) products that have been demonstrated to possess immunomodulatory properties. In this review we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode-secreted glycoprotein ES-62 and describe the intracellular signal transduction pathways it targets to achieve these effects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibody Formation / immunology
  • B-Lymphocytes / immunology
  • Filariasis / immunology
  • Filarioidea / immunology*
  • Glycoproteins / immunology
  • Helminth Proteins / immunology*
  • Humans
  • Macrophages / immunology
  • Phosphorylcholine / immunology
  • Signal Transduction / immunology*
  • T-Lymphocytes / immunology


  • ES-62 protein, Acanthocheilonema viteae
  • Glycoproteins
  • Helminth Proteins
  • Phosphorylcholine