Exposure to bisphenol A is associated with recurrent miscarriage

Hum Reprod. 2005 Aug;20(8):2325-9. doi: 10.1093/humrep/deh888. Epub 2005 Jun 9.


Background: Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities.

Methods: Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively.

Results: The mean+/-SD values for bisphenol A in patients were 2.59+/-5.23 ng/ml, significantly higher than the 0.77+/-0.38 ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage.

Conclusion: Exposure to bisphenol A is associated with recurrent miscarriage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Habitual / blood
  • Abortion, Habitual / chemically induced*
  • Abortion, Habitual / immunology
  • Adult
  • Antibodies, Antinuclear / blood
  • Antibodies, Antiphospholipid / blood
  • Benzhydryl Compounds
  • Environmental Exposure
  • Estrogens, Non-Steroidal / adverse effects*
  • Estrogens, Non-Steroidal / blood
  • Female
  • Humans
  • Killer Cells, Natural / immunology
  • Phenols / adverse effects*
  • Phenols / blood
  • Pregnancy
  • Progesterone / blood
  • Prolactin / blood
  • Thyrotropin / blood
  • Thyroxine / blood


  • Antibodies, Antinuclear
  • Antibodies, Antiphospholipid
  • Benzhydryl Compounds
  • Estrogens, Non-Steroidal
  • Phenols
  • Progesterone
  • Prolactin
  • Thyrotropin
  • bisphenol A
  • Thyroxine