Sample size requirements for stratified cluster randomization designs

Stat Med. 1992 Apr;11(6):743-50. doi: 10.1002/sim.4780110605.


Sample size requirements are provided for designs of studies in which clusters are randomized within each of several strata, where cluster size itself may be a stratifying factor. The approach generalizes a formula derived by Woolson et al., which provides sample size requirements for the Cochran-Mantel-Haenszel statistic. Issues of data analysis are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cluster Analysis*
  • Humans
  • Matched-Pair Analysis
  • Proportional Hazards Models*
  • Randomized Controlled Trials as Topic / standards*
  • Research Design / standards*
  • Sampling Studies*