CCR2/64I mutation detection in a HIV-1-positive patient with slow CD4 T-cell decline and delay in disease progression

Int J STD AIDS. 2005 May;16(5):392-4. doi: 10.1258/0956462053888817.

Abstract

Chemokine receptor genetic mutations are among the factors which have been shown to influence human susceptibility to HIV-1 infection and progression. The CCR2-64I mutation has been shown to delay HIV-1 disease progression in some studies. Here we show evidence of delayed disease progression, reflected in maintenance of a stable viral load and a slow CD4 T-cell decline, in a patient with the CCR2-64I gene. We then consider the potential value of identifying these genetic defects in the era of fusion/entry inhibiting therapeutics.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes / immunology
  • Disease Progression
  • Female
  • HIV Infections / genetics
  • HIV Infections / immunology*
  • HIV Infections / physiopathology*
  • HIV-1
  • Humans
  • Mutation*
  • Receptors, CCR2
  • Receptors, Chemokine / genetics*

Substances

  • CCR2 protein, human
  • Receptors, CCR2
  • Receptors, Chemokine