Effects of conditioning peripheral repetitive magnetic stimulation in patients with complex regional pain syndrome

Neurol Res. 2005 Jun;27(4):412-7. doi: 10.1179/016164105X17224.


Objectives: We tested whether repetitive magnetic stimulation (rMS) induces an afferent input to the spinocerebral tract in patients with complex regional pain syndrome (CRPS).

Methods: Cortical and spinal motor evoked potentials (cMEP and sMEP), as well as the contra- and ipsilateral silent period (cCSP and iCSP), were recorded in patients with CRPS type I before and after conditioning rMS, applied at cervical nerve roots innervating affected muscles. Patients were compared with a group of healthy subjects.

Results: In the group of patients we found that cMEP amplitudes were always significantly smaller for both hemispheres. In the group of healthy subjects we found a significant prolongation of the cCSP and iCSP after rMS. This was absent in patients. SMEP were always unchanged in both groups.

Discussion: This led us to the explanation that the afferent input to the motor cortical system in CRPS patients is less effective than in healthy subjects.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Cerebral Cortex / physiopathology*
  • Cerebral Cortex / radiation effects
  • Conditioning, Psychological / radiation effects*
  • Electric Stimulation / methods*
  • Electromyography / methods
  • Evoked Potentials, Motor / drug effects
  • Female
  • Functional Laterality
  • Humans
  • Magnetics*
  • Male
  • Middle Aged
  • Neural Conduction / radiation effects
  • Neural Inhibition / radiation effects
  • Reaction Time / radiation effects
  • Reflex Sympathetic Dystrophy / physiopathology*
  • Sensory Thresholds / radiation effects
  • Spinal Cord / physiopathology*
  • Spinal Cord / radiation effects
  • Time Factors