The D box asserts itself

Mol Cell. 2005 Jun 10;18(6):611-2. doi: 10.1016/j.molcel.2005.05.019.

Abstract

New findings (Burton et al., 2005; Kraft et al., 2005) demonstrate the direct recognition of D and KEN boxes, short sequence elements in substrates of the anaphase-promoting complex/cyclosome (APC/C), by APC/C coactivators and indicate a special role for the D box in the assembly of catalytically active APC/C.

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Motifs
  • Anaphase-Promoting Complex-Cyclosome
  • Autophagy-Related Proteins
  • Carrier Proteins / metabolism
  • Cdc20 Proteins
  • Cell Cycle Proteins / metabolism
  • Escherichia coli
  • Mutation
  • Substrate Specificity
  • Ubiquitin-Protein Ligase Complexes / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • Autophagy-Related Proteins
  • Carrier Proteins
  • Cdc20 Proteins
  • Cell Cycle Proteins
  • UBQLN1 protein, human
  • CDC20 protein, human
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome