Magnetic resonance spectroscopy as a measure of brain damage in multiple sclerosis

J Neurol Sci. 2005 Jun 15;233(1-2):203-8. doi: 10.1016/j.jns.2005.03.018. Epub 2005 Apr 20.


Recent MR studies have emphasised the importance of neuronal and axonal damage in multiple sclerosis. In this respect, proton MR spectroscopy (by monitoring levels of N-acetylaspartate, a putative marker of axonal integrity) has been particularly illuminating by showing indirect evidence of neurodegeneration in both lesional and non-lesional brain tissues from the earliest stages of the disease. The importance of these changes to patients' clinical disability argues for the primary role of neuronal pathology in the pathogenesis of the disease.

Publication types

  • Review

MeSH terms

  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Axons / pathology*
  • Brain Diseases / diagnosis*
  • Brain Diseases / etiology
  • Creatine / metabolism
  • Disability Evaluation
  • Humans
  • Magnetic Resonance Imaging / methods
  • Magnetic Resonance Spectroscopy / methods*
  • Multiple Sclerosis / complications
  • Multiple Sclerosis / diagnosis*
  • Severity of Illness Index


  • Aspartic Acid
  • Creatine