No association of the brain-derived neurotrophic factor (BDNF) gene C-270T polymorphism with schizophrenia

Schizophr Res. 2005 Jul 15;76(2-3):187-93. doi: 10.1016/j.schres.2005.02.006.


Brain-derived neurotrophic factor (BDNF) regulates a variety of neuromodulatory processes during development, as well as in adulthood. It has been proposed as a risk factor for schizophrenia. We have investigated a possible association between schizophrenia and the C-270T polymorphism in the brain-derived neurotrophic factor (BDNF) gene in 397 schizophrenic patients and 380 control subjects. The diagnosis of schizophrenia was made for each patient by at least two psychiatrists, using DSM-IV and ICD-10 criteria in structured clinical interviews for DSM-IV Axis I disorders (SCID). No association was found between schizophrenia and the analyzed polymorphism, for either genotype or allele distribution (for genotype: p=0.513, for alleles: p=0.812). Differences were not statistically significant when analyzed separately by sex. For males, the differences for genotype distribution and allele frequency were p=0.078 and p=0.162 respectively and for females: p=0.441 and p=0.315. Thus, our data indicate that variations in the BDNF gene are unlikely to be an important factor in susceptibility to schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Brain-Derived Neurotrophic Factor / genetics*
  • Female
  • Genotype
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Schizophrenia / genetics*


  • Brain-Derived Neurotrophic Factor