Module-assisted synthesis of the bifunctional labelling agent N-succinimidyl 4-[(18)F]fluorobenzoate ([(18)F]SFB)

Appl Radiat Isot. 2005 Sep;63(3):329-32. doi: 10.1016/j.apradiso.2005.03.005.


The three-step radiosynthesis of N-succinimidyl 4-[(18)F]fluorobenzoate ([(18)F]SFB) was adapted to a remotely controlled synthesis module. After optimization of the reaction conditions, the final [(18)F]SFB was obtained in decay-corrected radiochemical yields of 34-38% (related to [(18)F]fluoride; n=12) within a synthesis time of 68 min. The radiochemical purity was in the range of 93-96%.

MeSH terms

  • Benzoates / chemical synthesis*
  • Fluorine Radioisotopes / chemistry*
  • Humans
  • Isotope Labeling / methods
  • Positron-Emission Tomography / methods
  • Radiopharmaceuticals / chemical synthesis*
  • Succinimides / chemical synthesis*


  • Benzoates
  • Fluorine Radioisotopes
  • Radiopharmaceuticals
  • Succinimides
  • N-succinimidyl-4-fluorobenzoate