Abstract
A randomized clinical trial was conducted with 239 women at nine clinical research sites to compare bleeding profile, headache frequency, and subject satisfaction with the transdermal contraceptive, ORTHO EVRA (norelgestromin/ethinyl estradiol transdermal system) used in an extended regimen (84 days) with a traditional, 28-day cyclic regimen. In a majority of women studied, compared with cyclic use, extended use of transdermal norelgestromin/ethinyl estradiol delayed menses and reduced the total incidence of mean headache days during the hormone-free interval.
Publication types
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Comparative Study
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Cutaneous
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Adolescent
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Adult
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Delayed-Action Preparations
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Drug Combinations
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Ethisterone / administration & dosage
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Ethisterone / analogs & derivatives*
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Female
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Headache / drug therapy*
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Headache / prevention & control
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Humans
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Middle Aged
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Norgestrel / administration & dosage
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Norgestrel / analogs & derivatives*
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Oximes / administration & dosage
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Substance Withdrawal Syndrome / drug therapy*
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Substance Withdrawal Syndrome / prevention & control
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Time Factors
Substances
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Delayed-Action Preparations
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Drug Combinations
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Oximes
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Norgestrel
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Ethisterone
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norelgestromin