A new bradykinin-potentiating peptide (peptide P) isolated from the venom of Bothrops jararacussu (jararacuçu tapete, urutu dourado)

L A Ferreira; O B Henriques; I Lebrun; M B Batista; B C Prezoto; A S Andreoni; R Zelnik; G Habermehl

doi:10.1016/0041-0101(92)90499-u

A new bradykinin-potentiating peptide (peptide P) isolated from the venom of Bothrops jararacussu (jararacuçu tapete, urutu dourado)

Toxicon. 1992 Jan;30(1):33-40. doi: 10.1016/0041-0101(92)90499-u.

Authors

L A Ferreira¹, O B Henriques, I Lebrun, M B Batista, B C Prezoto, A S Andreoni, R Zelnik, G Habermehl

Affiliation

¹ Serviço de Bioquímica-Lab, Cininas, Instituto Butantan, São Paulo, Brazil.

PMID: 1595077
DOI: 10.1016/0041-0101(92)90499-u

Abstract

Several bradykinin potentiators were identified in the venom of Bothrops jararacussu by chromatographic techniques and biological assays. One of them which was isolated inhibited the angiotensin-converting enzyme in vitro and potentiated the bradykinin-induced lowering of the arterial pressure in the rat.

MeSH terms

Angiotensin-Converting Enzyme Inhibitors / pharmacology
Animals
Blood Pressure / drug effects
Bradykinin / pharmacology*
Captopril / pharmacology
Chromatography, Gel
Chromatography, High Pressure Liquid
Crotalid Venoms / chemistry
Crotalid Venoms / pharmacology*
Drug Synergism
Female
Guinea Pigs
Ileum
Male
Muscle Contraction / drug effects
Muscle, Smooth / drug effects*
Oligopeptides / chemistry
Oligopeptides / isolation & purification
Oligopeptides / pharmacology*
Organ Culture Techniques
Rats
Snakes

Substances

Angiotensin-Converting Enzyme Inhibitors
Crotalid Venoms
Oligopeptides
bradykinin potentiating factors
Captopril
Bradykinin