Soluble mesothelin-related protein--a blood test for mesothelioma

Lung Cancer. 2005 Jul;49 Suppl 1:S109-11. doi: 10.1016/j.lungcan.2005.03.020.


Identification of tumor marker for mesothelioma (MM) might prove useful in diagnosis as well as for monitoring tumor in response to therapy and for screening at-risk individuals. We tested the hypothesis that soluble mesothelin-related protein (SMRP), a mesothelin family member, in the serum would be such a marker. Our data show that determination of SMRP in serum is a marker of MM with a sensitivity of sensitivity 83% and specificity 95% in the first 48 MM patients tested. Changes in serum SMRP levels parallel clinical course/tumor size and SMRP is elevated in 75% of patients at diagnosis. SMRP should also be useful for monitoring disease progression, and importantly, may prove useful for screening asbestos-exposed individuals for early MM.

MeSH terms

  • Adult
  • Asbestos / adverse effects
  • Biomarkers, Tumor / blood*
  • GPI-Linked Proteins
  • Humans
  • Lung Diseases / etiology
  • Lung Diseases / physiopathology
  • Membrane Glycoproteins / blood*
  • Mesothelin
  • Mesothelioma / blood
  • Mesothelioma / diagnosis*
  • Pleural Neoplasms / blood
  • Pleural Neoplasms / diagnosis*


  • Biomarkers, Tumor
  • GPI-Linked Proteins
  • Membrane Glycoproteins
  • Asbestos
  • Mesothelin