5-HT 1A polymorphism and self-transcendence in mood disorders

Am J Med Genet B Neuropsychiatr Genet. 2005 Aug 5;137B(1):33-5. doi: 10.1002/ajmg.b.30111.


Recently, an association between serotonin 1A receptor binding potential and self-transcendence scores at the temperament and character inventory (TCI) has been reported. We tested involvement of 5-HT(1A) gene in this trait, in a sample of 40 remitted mood disorder patients. Subjects with the 5-HT(1A)*C/C genotype showed significantly lower scores at the total self-transcendence and at the sub-scales of transpersonal identification and spiritual acceptance. Our preliminary results further support the involvement of the serotoninergic pattern in the self-transcendence character trait.

MeSH terms

  • Adult
  • Alleles
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mood Disorders / genetics*
  • Mood Disorders / psychology
  • Polymorphism, Genetic*
  • Psychiatric Status Rating Scales
  • Receptor, Serotonin, 5-HT1A / genetics*
  • Self Concept*


  • Receptor, Serotonin, 5-HT1A