MSI1-like proteins: an escort service for chromatin assembly and remodeling complexes

Trends Cell Biol. 2005 Jun;15(6):295-302. doi: 10.1016/j.tcb.2005.04.004.


MSI1-like WD40 repeat proteins are subunits of many protein complexes controlling chromatin dynamics. These proteins do not have any catalytic activity, but several recent studies using loss-of-function mutants established specific functions during development. Here, we review the current knowledge of MSI1-like proteins, including their phylogenetic history, expression patterns, biochemical interactions and mutant phenotypes. MSI1-like proteins, which are often targets or partners of tumor-suppressor proteins, are required during cell proliferation and differentiation in flies, nematodes and plants. We discuss the possibility that MSI1-like proteins could function to maintain epigenetic memory during development by targeting silencing complexes to chromatin during nucleosome assembly.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Chromatin / genetics
  • Chromatin / metabolism*
  • Chromatin Assembly and Disassembly*
  • Histones / metabolism
  • Humans
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*
  • Protein Binding


  • Chromatin
  • Histones
  • Microfilament Proteins