Ral GTPases: corrupting the exocyst in cancer cells

Trends Cell Biol. 2005 Jun;15(6):327-32. doi: 10.1016/j.tcb.2005.04.002.

Abstract

The Ras-like small G-proteins RalA and RalB have achieved some notoriety as components of one of a growing variety of candidate Ras effector pathways. Recent work has demonstrated that Ral GTPase activation is required to support both the initiation and maintenance of tumorigenic transformation of human cells. The mechanistic basis for this support remains to be defined. However, the discovery that the exocyst is a direct effector complex for activated Ral proteins suggests that mobilization of polarized exocytosis might be a basic component of the biological framework supporting tumorigenic progression.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic
  • Exocytosis*
  • Humans
  • Membrane Proteins / metabolism*
  • Neoplasms / metabolism*
  • Neoplasms / pathology*
  • Protein Binding
  • ral GTP-Binding Proteins / metabolism*

Substances

  • Membrane Proteins
  • ral GTP-Binding Proteins