Lung cancer screening with low-dose helical CT in Korea: experiences at the Samsung Medical Center

J Korean Med Sci. 2005 Jun;20(3):402-8. doi: 10.3346/jkms.2005.20.3.402.


To determine overall detection rates of lung cancer by low-dose CT (LDCT) screening and to compare histopathologic and imaging differences of detected cancers between high- and low-risk groups, this study included 6,406 asymptomatic Korean adults with >or=45 yr of age who underwent LDCT for lung cancer screening. All were classified into high- (>or=20 pack-year smoking; 3,353) and low-risk (3,053; <20 pack-yr smoking and non-smokers) groups. We compared CT findings of detected cancers and detection rates between high- and low-risk. At initial CT, 35% (2,255 of 6,406) had at least one or more non-calcified nodule. Lung cancer detection rates were 0.36% (23 of 6,406). Twenty-one non-small cell lung cancers appeared as solid (n=14) or ground-glass opacity (GGO) (n=7) nodules. Cancer likelihood was higher in GGO nodules than in solid nodules (p<0.01). Fifteen of 23 cancers occurred in high-risk group and 8 in low-risk group (p=0.215). Therefore, LDCT screening help detect early stage of lung cancer in asymptomatic Korean population with detection rate of 0.36% on a population basis and may be useful for discovering early lung cancer in low-risk group as well as in high-risk group.

Publication types

  • Comparative Study

MeSH terms

  • Adenocarcinoma / diagnosis
  • Aged
  • Aged, 80 and over
  • Carcinoma, Non-Small-Cell Lung / diagnosis
  • Carcinoma, Squamous Cell / diagnosis
  • Female
  • Humans
  • Korea
  • Lung Neoplasms / diagnosis*
  • Male
  • Mass Screening / methods*
  • Middle Aged
  • Risk Factors
  • Tomography, X-Ray Computed / methods*