Abstract
Writer's cramp (WC) is a form of focal task-specific dystonia, which is brought on by writing. Although most cases are sporadic, a positive family history is present in 5% to 20% of cases. To date, WC has been reported in several families with primary torsion dystonia, including DYT7, a pure focal dystonia, and in the mixed dystonias, DYT1, DYT6, and DYT13. We describe a family of Bulgarian descent with three brothers presenting with a very-late-onset dystonic WC, compatible with linkage to chromosome 18p.
Copyright (c) 2005 Movement Disorder Society.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Age Factors
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Aged
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Chromosomes, Human, Pair 8 / genetics*
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DNA / analysis
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Dystonia Musculorum Deformans / genetics
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Dystonia Musculorum Deformans / physiopathology
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Dystonic Disorders / genetics*
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Dystonic Disorders / physiopathology*
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Genetic Markers
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Humans
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Male
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Molecular Chaperones / genetics
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Severity of Illness Index
Substances
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Genetic Markers
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Molecular Chaperones
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TOR1A protein, human
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DNA