Three brothers with a very-late-onset writer's cramp

Mov Disord. 2005 Oct;20(10):1375-7. doi: 10.1002/mds.20568.

Abstract

Writer's cramp (WC) is a form of focal task-specific dystonia, which is brought on by writing. Although most cases are sporadic, a positive family history is present in 5% to 20% of cases. To date, WC has been reported in several families with primary torsion dystonia, including DYT7, a pure focal dystonia, and in the mixed dystonias, DYT1, DYT6, and DYT13. We describe a family of Bulgarian descent with three brothers presenting with a very-late-onset dystonic WC, compatible with linkage to chromosome 18p.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Aged
  • Chromosomes, Human, Pair 8 / genetics*
  • DNA / analysis
  • Dystonia Musculorum Deformans / genetics
  • Dystonia Musculorum Deformans / physiopathology
  • Dystonic Disorders / genetics*
  • Dystonic Disorders / physiopathology*
  • Genetic Markers
  • Humans
  • Male
  • Molecular Chaperones / genetics
  • Severity of Illness Index

Substances

  • Genetic Markers
  • Molecular Chaperones
  • TOR1A protein, human
  • DNA