Cardiovascular calcification in Hispanic Americans (HA) with chronic kidney disease (CKD) due to type 2 diabetes

Kidney Int. 2005 Jul;68(1):271-7. doi: 10.1111/j.1523-1755.2005.00402.x.

Abstract

Background: Cardiovascular calcification (CVC) is common and severe in patients with end-stage renal disease on dialysis. However, the prevalence and severity of CVC is less well documented in patients with chronic kidney disease (CKD) not yet on dialysis.

Methods: Fifty-eight nondialyzed HA with type 2 diabetes and CKD were enrolled. They comprise 29 patients with stages 1 and 2 CKD (early CKD group) and 26 patients with stages 4 and 5 CKD (advanced CKD group). Coronary artery calcification (CAC) was measured by ultrafast spiral computed tomography, while peripheral artery calcification (PAC) was evaluated by plain x-ray of the chest, pelvis, thighs, and lower extremities.

Results: The prevalence of CAC and PAC were significantly higher in the advanced CKD group compared to the early CKD group (73% vs. 38%; P < 0.01 and 85% vs. 35%; P < 0.0001, respectively). The median CAC scores were 18-fold greater in the advanced CKD group (138.9 vs. 7.8, respectively). By linear regression analysis, a strong association was found between the level of renal function and ln total volume of CAC.

Conclusion: Our data indicate that CAC and PAC are common and severe in HA diabetic patients with CKD not previously treated with dialysis, calcium-based phosphate binders, or vitamin D analogues. Lower level of renal function is associated with increased burden of vascular calcification in predialysis patients with CKD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Calcinosis / diagnostic imaging
  • Calcinosis / ethnology*
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / ethnology*
  • Diabetes Mellitus, Type 2 / ethnology*
  • Diabetic Nephropathies / diagnostic imaging
  • Diabetic Nephropathies / ethnology*
  • Female
  • Hispanic Americans / statistics & numerical data*
  • Humans
  • Kidney Failure, Chronic / diagnostic imaging
  • Kidney Failure, Chronic / ethnology
  • Male
  • Middle Aged
  • Peripheral Vascular Diseases / diagnostic imaging
  • Peripheral Vascular Diseases / ethnology
  • Prevalence
  • Severity of Illness Index
  • Tomography, Spiral Computed